5th November 2019
These are the latest Guidelines for the management of hereditary colorectal cancer from the BSG /ACPGBI/UKCGG. This guideline for the management of hereditary CRC is an update from the 2010 ‘British Society of Gastroenterology / Association of Coloproctology of Great Britain and Ireland (BSG/ACPGBI) guidelines for colorectal screening and surveillance in moderate and high-risk groups’, however this guideline is concerned specifically with people who have increased lifetime risk of CRC due to hereditary factors. On this occasion the UK Cancer Genetics Group (UKCGG), a subgroup within the British Society of Genetic Medicine (BSGM), worked as a partner to BSG and ACPGBI in the multidisciplinary guideline development process. The guideline body invited external review through the Delphi process by members of the public as well as the steering committees of the European Hereditary Tumour Group (EHTG) and the European Society of Gastrointestinal Endoscopy (ESGE). A systematic review of 10,189 publications was undertaken to develop 67 evidence and expert opinion based-recommendations for the management of hereditary CRC risk. Ten research recommendations are also prioritised to inform clinical management of people at hereditary CRC risk.